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KMID : 0388219950020010087
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Journal of the Korean Rheumatism Association
1995 Volume.2 No. 1 p.87 ~ p.91
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A Case of D-Penicillamine Induced Polymyositis
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김승영
김태환/김평남/전재범/정성수/이인홍/배상철/유대현/김성윤
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Abstract
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polymyositis can develop infrequently as one of the autoimmune complications of D-penicillamine treatment, but its exact pathogenesis remains unclear. Suspicion of D-penicillamine induced polymyositis should be followed by immediate drug
withdrawal
and
confirmation of diagnosis by determination of muscle enzymes, EMG and biopsy. Most patients recover from polymyositis completely within 6 months after drug withdrawal, even though steroid may be used in severe conditions. Suspicion of
pre-existing
low-grade myopathy or myositis should possibly be regarded as a relative contraindication to D-penicillamine treatment and analysis of juscle enzymes should be followed regularly. We experienced a case of rheumatoid arthritis who developed
polymyositis
after treatment of D-penicillamine for about 5 weeks(total dosage 3500mg) in a 47-year-old female and report this wit a review of literature.
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